Hydrazine → HCID 86725383, compound

HRID 1503828Notes

Reaction equation

HRID 1503828 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[C:19]([F:20])=[CH:18][C:17]([N:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]3)=[CH:16][C:15]=2[F:34])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].[NH2:35][NH2:36]>O1CCOCC1>[C:1]([C:4]1[C:5]([NH:13][C:14]2[C:19]([F:20])=[CH:18][C:17]([N:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]3)=[CH:16][C:15]=2[F:34])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1[NH:35][NH2:36])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 86725384Tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)-3,5-difluorophenyl)piperazine-1-carboxylate

Product 1

HCID 86725383HCID 86725383, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of Example 16E (380 mg, 0.74 mmol) in 1,4-dioxane (10 mL) was added hydrazine (185 mg, 3.68 mmol) and the mixture was stirred at ambient temperature for 3 hours. The mixture was concentrated and the residue was recrystallized from ethanol to give the title compound. MS: 495 (M+H+).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-1475072c529044b2b2a22eefcc38f2bb
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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