HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → HCID 86725383, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Tert-butyl 4-(4-(5-carbamoyl-6-chloro-2-(methylthio)pyrimidin-4-ylamino)-3,5-difluorophenyl)piperazine-1-carboxylate | HCID 86725384 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86725383 | HCID 86725383 | — |
Reaction Steps
To a solution of the product of Example 16E (380 mg, 0.74 mmol) in 1,4-dioxane (10 mL) was added hydrazine (185 mg, 3.68 mmol) and the mixture was stirred at ambient temperature for 3 hours. The mixture was concentrated and the residue was recrystallized from ethanol to give the title compound. MS: 495 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212192B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-1475072c529044b2b2a22eefcc38f2bb |
| Source note | uspto-grants-2015_12 |