Trimethyl orthoformate → HCID 86725385, compound

HRID 1503829Notes

Reaction equation

HRID 1503829 reaction equation
[C:1]([C:4]1[C:5]([NH:14][C:15]2[C:20]([F:21])=[CH:19][C:18]([N:22]3[CH2:27][CH2:26][N:25]([C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:24][CH2:23]3)=[CH:17][C:16]=2[F:35])=[N:6][C:7]([S:12][CH3:13])=[N:8][C:9]=1[NH:10][NH2:11])(=[O:3])[NH2:2].[CH3:36]OC(OC)OC>CN(C)C=O>[C:1]([C:4]1[C:9]2[N:8]([CH:36]=[N:11][N:10]=2)[C:7]([S:12][CH3:13])=[N:6][C:5]=1[NH:14][C:15]1[C:16]([F:35])=[CH:17][C:18]([N:22]2[CH2:23][CH2:24][N:25]([C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[CH2:26][CH2:27]2)=[CH:19][C:20]=1[F:21])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 9005Trimethyl orthoformateHCID 86725383HCID 86725383, compound

Product 1

HCID 86725385HCID 86725385, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of the product of Example 16F (615 mg, 1.2 mmol) and trimethoxymethane (5 g, 46.9 mmol) in N,N-dimethylformamide (10 mL) was stirred at ambient temperature for 1 hour and at 55° C. for 3 hours. The mixture was filtered to give the title compound. MS: 495 (M+H+).

Workup

  1. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-a2b301512da54c759986374f2a50d2da
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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