Hydrazine hydrate (1:1) → HCID 86725391, compound

HRID 1503839Notes

Reaction equation

HRID 1503839 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]3)=[CH:16][C:15]=2[F:33])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].O.[NH2:35][NH2:36]>O1CCOCC1>[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([N:20]3[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]3)=[CH:16][C:15]=2[F:33])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1[NH:35][NH2:36])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86725392HCID 86725392, compound

Product 1

HCID 86725391HCID 86725391, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of Example 28C (497 mg, 1 mmol) in 1,4-dioxane (10 mL) was added hydrazine hydrate (0.3 mL). After stirring at ambient temperature for about 4 hours, the mixture was concentrated. The residue was washed with hexane and dried under vacuum to give the title compound, which was used in the next step without further purification. MS: 493 (M+H+).

Workup

  1. concentrationthe mixture was concentrated
  2. washThe residue was washed with hexane
  3. customdried under vacuum

Sources & evidence

ORD record
ord-4531f27aee774448ad182140124710e7
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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