Trifluoroacetic acid → HCID 70557489, compound

HRID 1503858Notes

Reaction equation

HRID 1503858 reaction equation
C(OC([N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)=[CH:11][C:10]=1[Cl:28])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:28][C:10]1[CH:11]=[C:12]([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[CH:13]=[CH:14][C:9]=1[NH2:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86725400HCID 86725400, compound

Product 1

HCID 70557489HCID 70557489, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of the product of EXAMPLE 42B (320 mg, 0.63 mmol) in dichloromethane (4 mL) was added trifluoroacetic acid (1 mL) dropwise and the mixture was stirred at ambient temperature for 4 hours. The solvent was removed and the crude title compound was used in the next step without further purification. MS: 212 (M+H+).

Workup

  1. customThe solvent was removed
  2. customthe crude title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-c5b1654cc0ca43eeb82de706ec48f92b
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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