HCID 86725407, compound → HCID 86725408, compound

HRID 1503874Notes

Reaction equation

HRID 1503874 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[C:14]([F:15])=[CH:13][C:12]([N:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]2)=[C:11]([CH3:29])[CH:10]=1)C1C=CC=CC=1>[Pd].CO>[NH2:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([N:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH2:18][CH2:17]2)=[C:11]([CH3:29])[CH:10]=1

Participants

4

Reactant 1

HCID 86725407HCID 86725407, compound

Product 1

HCID 86725408HCID 86725408, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of the product of Example 51B (2 g, 4.1 mmol) and 10% palladium on carbon (200 mg) in methanol (100 mL) was stirred under hydrogen for 18 hours. The catalyst was filtered and the filtrate was concentrated and the residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with 1/1 petroleum ether/ethyl acetate to give the title compound. MS: 310 (M+H+).

Workup

  1. filtrationThe catalyst was filtered
  2. concentrationthe filtrate was concentrated
  3. customthe residue was purified by flash chromatography on silica gel (200-300 mesh)
  4. washeluting with 1/1 petroleum ether/ethyl acetate

Sources & evidence

ORD record
ord-8284e4034d8b461597583f517fab17e4
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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