Hydrazine hydrate (1:1) → HCID 86725413, compound

HRID 1503883Notes

Reaction equation

HRID 1503883 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH:20]3[CH2:25][CH2:24][N:23]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:22][CH2:21]3)=[CH:16][C:15]=2[Cl:33])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].O.[NH2:35][NH2:36]>O1CCOCC1>[C:1]([C:4]1[C:5]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([CH:20]3[CH2:21][CH2:22][N:23]([C:26]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:27])[CH2:24][CH2:25]3)=[CH:16][C:15]=2[Cl:33])=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1[NH:35][NH2:36])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86725414HCID 86725414, compound

Product 1

HCID 86725413HCID 86725413, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of Example 55A (131 mg, 0.26 mmol) in 1,4-dioxane (3 mL) was added hydrazine hydrate (50 mg, 0.78 mmol) and the mixture was stirred at ambient temperature for 4 hours. The mixture was concentrated and the residue was washed with hexane and dried to give the title compound. The crude title compound was used in the next step without further purification. MS: 508 (M+H+).

Workup

  1. concentrationThe mixture was concentrated
  2. washthe residue was washed with hexane
  3. customdried

Sources & evidence

ORD record
ord-e2072270487148a79c74603bf1b1d192
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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