Trifluoroacetic acid → HCID 70557529, compound

HRID 1503888Notes

Reaction equation

HRID 1503888 reaction equation
C(OC([N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)=[CH:11][C:10]=1[Cl:28])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:28][C:10]1[CH:11]=[C:12]([CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH:13]=[CH:14][C:9]=1[NH2:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86725419HCID 86725419, compound

Product 1

HCID 70557529HCID 70557529, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture the product of Example 60C (100 mg) and trifluoroacetic acid (1 mL) in dichloromethane (4 mL) was stirred at ambient temperature for 3 hours. The mixture was concentrated and the crude title compound was used in the next step without further purification. MS: 211 (M+H+).

Workup

  1. concentrationThe mixture was concentrated
  2. customthe crude title compound was used in the next step without further purification

Sources & evidence

ORD record
ord-37669dbca99e49e48aea413eb5d13610
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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