Hydrochloric Acid → HCID 118567410, compound

HRID 1503914Notes

Reaction equation

HRID 1503914 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([CH2:11][C@H:12]2[CH2:23][CH2:22][C:21]3[S:20][C:19]4[N:18]=[CH:17][N:16]=[C:15]([O:24][CH:25]5[CH2:30][CH2:29][CH:28]([N:31](C)[C:32](=O)OC(C)(C)C)[CH2:27][CH2:26]5)[C:14]=4[C:13]2=3)=[O:10])=[N:6][CH:7]=1.[ClH:40]>ClCCl>[ClH:40].[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:10])[CH2:11][C@H:12]2[CH2:23][CH2:22][C:21]3[S:20][C:19]4[N:18]=[CH:17][N:16]=[C:15]([O:24][CH:25]5[CH2:30][CH2:29][CH:28]([NH:31][CH3:32])[CH2:27][CH2:26]5)[C:14]=4[C:13]2=3)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68115531HCID 68115531, compound

Product 1

HCID 118567410HCID 118567410, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 25-mL round-bottom flask containing a solution of 36.1 (200 mg, 0.36 mmol, 1.00 equiv) in dichloromethane (15 mL) was added hydrochloric acid (12 M, 2 mL) at 0° C. under nitrogen. The resulting solution was stirred for 2 h at room temperature and concentrated under vacuum to afford N-(5-fluoropyridin-2-yl)-2-[(3R)-12-[[4-(methylamino)cyclohexyl]oxy]-7-thia-9,11-diazatricyclo[6.4.0.0^[2,6]]dodeca-1(8),2(6),9,11-tetraen-3-yl]acetamide hydrochloride (130 mg, crude), which was used in the next step without further purification.

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-d5bdc1aae96245b9901937b2c61a24fc
Source dataset
uspto-grants-2015_12
Patent number
US09212190B2

Reaction notes

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