Potassium Carbonate → (2R,3S,4S,5R)-2,3,4,5,6-pentahydroxyhexanal

Participants

Reaction Steps

Using a similar procedure as outlined in Example 4 and shown in FIG. 2 (with either pyridine or potassium carbonate as base), 2,6-diamino-2,6-dideoxy-D-galactose is reacted with acryloyl chloride to yield N,N-(2,6-deoxy-D-galactose)-2,6-acrylamide, galactose-derived N-((5-acrylamido-3,4,6-trihydroxytetrahydro-2H-pyran-2-yl)methyl)acrylamide.

Provenance & Evidence