Hydrochloric Acid → HCID 67217310, compound

Participants

Reaction Steps

Concentrated aqueous HCl) 0.5 ml) was added to a solution of 1,3,3-trimethyl-6,7-bis(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-2-oxabicyclo[2.2.2]octane 0.8 g, 10 mmol) in methanol (30 ml). The solution was stirred over night at ambient temperature after which time no traces of starting material were present by TLC (SiO2/CHCl3/MeOH, 100:1, (v/v)). The solution was filtered, concentrated and the residue was dissolved in CHCl3 and dried (K2CO3) to yield (2.46 g. 9 mmol, 90%) as a yellow oil.

Provenance & Evidence