Hydrochloric Acid → HCID 67217310, compound

HRID 1504110Notes

Reaction equation

HRID 1504110 reaction equation
Cl.[CH3:2][C:3]12[CH:20]([O:21][CH2:22][CH2:23][O:24]C3CCCCO3)[CH2:19][CH:6]([CH2:7][CH:8]1[O:9][CH2:10][CH2:11][O:12]C1CCCCO1)[C:5]([CH3:32])([CH3:31])[O:4]2>CO>[CH3:2][C:3]12[CH:20]([O:21][CH2:22][CH2:23][OH:24])[CH2:19][CH:6]([CH2:7][CH:8]1[O:9][CH2:10][CH2:11][OH:12])[C:5]([CH3:32])([CH3:31])[O:4]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67217297HCID 67217297, compound

Product 1

HCID 67217310HCID 67217310, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated aqueous HCl) 0.5 ml) was added to a solution of 1,3,3-trimethyl-6,7-bis(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)-2-oxabicyclo[2.2.2]octane 0.8 g, 10 mmol) in methanol (30 ml). The solution was stirred over night at ambient temperature after which time no traces of starting material were present by TLC (SiO2/CHCl3/MeOH, 100:1, (v/v)). The solution was filtered, concentrated and the residue was dissolved in CHCl3 and dried (K2CO3) to yield (2.46 g. 9 mmol, 90%) as a yellow oil.

Workup

  1. filtrationThe solution was filtered
  2. concentrationconcentrated
  3. dissolutionthe residue was dissolved in CHCl3
  4. dry with materialdried (K2CO3)
  5. customto yield (2.46 g. 9 mmol, 90%) as a yellow oil

Sources & evidence

ORD record
ord-d6d6712e11b2485087e934c5b9cfea20
Source dataset
uspto-grants-2015_12
Patent number
US09212257B2

Reaction notes

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