Hydrogen chloride-ethyl acetate → HCID 70656066, compound

HRID 1504130Notes

Reaction equation

HRID 1504130 reaction equation
C(OC(=O)C)C.[ClH:7].C(OC(=O)[NH:14][CH2:15][CH2:16][C:17]1[CH:34]=[CH:33][C:20]2[N:21]([CH2:31][CH3:32])[C:22](=[O:30])[C:23]([CH3:29])([CH3:28])[C:24](=[O:27])[N:25]([CH3:26])[C:19]=2[CH:18]=1)(C)(C)C>C(OCC)(=O)C>[ClH:7].[NH2:14][CH2:15][CH2:16][C:17]1[CH:34]=[CH:33][C:20]2[N:21]([CH2:31][CH3:32])[C:22](=[O:30])[C:23]([CH3:28])([CH3:29])[C:24](=[O:27])[N:25]([CH3:26])[C:19]=2[CH:18]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 669600582-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yl)ethyl carbamic acid tert-butyl ester

Product 1

HCID 70656066HCID 70656066, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 4N-hydrogen chloride ethyl acetate solution(6 ml) was added to an ethyl acetate solution (20 ml) of [2-(1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-7-yl)ethyl]carbamic acid tert-butyl ester(0.38 g), and the mixture was stirred at room temperature overnight. The reaction mixture was condensed under reduced pressure to give the title compound(0.26 g) as a pale orange amorphous solid.

Workup

  1. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-6ddd051ff76542a49d5a59a8b4535be5
Source dataset
uspto-grants-2015_12
Patent number
US09212187B2

Reaction notes

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