反应详情

Potassium carbonate (2.0 g) was added to a methanol solution (30 mL) of (3-((((1-ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-yl)methyl)(2-(2-methyl-4-oxofuro[3,2-c]pyridin-5(4H)-yl)ethyl)amino)methyl)pyridin-2-yl)methyl acetate (3.0 g) and the mixture was stirred overnight at room temperature. The resulting mixture was filtered and evaporated. The residue was purified by column-chromatography (methanol: ethyl acetate=0:100→1:9) to give the titled compound as ivory powder (1.95 g).

1. filtrationThe resulting mixture was filtered
2. customevaporated
3. customThe residue was purified by column-chromatography (methanol: ethyl acetate=0:100→1:9)