反应详情

温度

0 °C

N-(1-Ethyl-3,3,5-trimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-7-ylmethyl)-N-(2-methyl-6-oxo-1,6-dihydropyridin-3-ylmethyl)carbamic acid tert-butyl ester (536 mg) was dissolved in DMF(20 ml), and was cooled to 0° C. in ice water bath. Sodium hydride (60% in oil, 56.1 mg) was added thereto at the same temperature, and the mixture was stirred at 0° C. for 0.5 hours. Methyl iodide (0.081 ml) was added thereto, and the mixture was stirred at 0° C. for 0.5 hours. Water was added to the reaction mixture, followed by extraction using ethyl acetate. The organic layer was dried with sodium sulfate, and was condensed under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate: methanol=10:1). The purified product was condensed to dryness under reduced pressure to give the title compound(550 mg) as a yellow oil.

1. stirringthe mixture was stirred at 0° C. for 0.5 hours
2. extractionfollowed by extraction
3. dry with materialThe organic layer was dried with sodium sulfate
4. customcondensed under reduced pressure
5. customThe residue was purified by silica gel column chromatography (ethyl acetate: methanol=10:1)
6. customcondensed to dryness under reduced pressure