Sodium Iodide → HCID 66961269, compound

HRID 1504162Notes

Reaction equation

HRID 1504162 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][C:12](=[O:17])[N:13]2[CH3:16])=[CH:8][CH:7]=1.[I-:18].[Na+].C(#N)C>O>[I:18][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[CH:11][C:12](=[O:17])[N:13]2[CH3:16])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 5238Sodium IodideHCID 6342AcetonitrileHCID 66960691HCID 66960691, compound

Product 1

HCID 66961269HCID 66961269, compoundYield 70.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

7-(3-Chloropropoxy)-1-methyl-1H-quinolin-2-one(2.5 g) and sodium iodide(3.0 g) were added to 30 ml of acetonitrile. The mixture was stirred for 18 hours while heated under reflux. After cooled to room temperature, water was added to the reaction mixture, followed by extraction using dichloromethane. The organic layer was dried with sodium sulfate and was condensed under reduced pressure to give the title compound(2.4 g) as a pale brown powder.

Workup

  1. temperaturewhile heated
  2. temperatureunder reflux
  3. extractionfollowed by extraction
  4. dry with materialThe organic layer was dried with sodium sulfate
  5. customcondensed under reduced pressure

Sources & evidence

ORD record
ord-fcf5c4d745ed4119b4c8bf3c3346350a
Source dataset
uspto-grants-2015_12
Patent number
US09212187B2

Reaction notes

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