反应详情

A 1N-hydrogen chloride ethanol solution(1.7 ml) was added to an ethanol solution (10 ml) of 1-Methyl-6-{2-[(2-pyridin-3-ylethyl)pyridin-3-ylmethylamino]ethoxy}-1H-quinolin-2-one(195 mg), which was stirred at room temperature. The reaction mixture was condensed under reduced pressure and ethyl acetate was added to the residue. The precipitated insoluble matter was separated, washed with ethyl acetate, and dried to give the title compound(199 mg) as a pale yellow powder.

1. additionwas added to the residue
2. customThe precipitated insoluble matter was separated
3. washwashed with ethyl acetate
4. customdried