反应详情

Into a THF (25 mL)-MeOH (25 mL) mixed solvent solution of 4-benzyloxy-1-{4-[(2-tetrahydropyranyl)oxy]phenyl}-1H-pyridin-2-one (Step (1) of Example 12, 2.05 g, 5.4 mmols), 10% palladium-on-carbon (600 mg) was added. The atmosphere was hydrogen-substituted, and the reaction system was stirred at room temperature for 3.5 hours. The reaction liquid was filtered, the solvent was concentrated under reduced pressure, methanol was added to the resulting residue and the precipitate was recovered by filtration. Drying the same, the title compound (1.25 g, 80%) was obtained.

1. additionwas added
2. customThe reaction liquid
3. filtrationwas filtered
4. concentrationthe solvent was concentrated under reduced pressure, methanol
5. additionwas added to the resulting residue
6. filtrationthe precipitate was recovered by filtration
7. dry with materialDrying the same, the title compound (1.25 g, 80%)
8. customwas obtained