反应详情

温度

60 °C

Sodium ethoxide(34 mg) was added to an ethanol solution (5 ml) of 6-(3-amino-propoxy)-1-methyl-1H-quinolin-2-one (116 mg) and 3-chloro-N-o-tolyl-propionamide(148 mg). The mixture was stirred at 60° C. for 5 hours. The reaction mixture was condensed under reduced pressure. The residue was purified by silica gel column chromatography (dichloromethane: methanol=20:1→10:1). The purified product was condensed under reduced pressure to give the title compound(115 mg) as a white powder.

1. customcondensed under reduced pressure
2. customThe residue was purified by silica gel column chromatography (dichloromethane: methanol=20:1→10:1)
3. customcondensed under reduced pressure