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HRID1504257

反应详情

EQUATION

反应方程式

HRID 1504257 的结构方程式

REACTANTS

反应物

2
结构：O=C1C=CC(=O)C=C1
HCID4650

1,4-Benzoquinone

C6H4O2

结构：CC=CN1CCOCC1
HCID54425487

4-(Prop-1-en-1-yl)morpholine

C7H13NO

PRODUCTS

生成物

1
结构：CC1c2cc(O)ccc2OC1N1CCOCC1
HCID13872995

3-Methyl-2-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-ol

C13H17NO3

收率 96.4%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Benzoquinone (300 g, 2.8 mol) was added in toluene (1.5 L) and cooled with a dry ice/isopropyl alcohol (IPA) bath. 4-Propenyl-morpholine (prepared as above in EXAMPLE I) (380 g, 3 mol) was added dropwise with stirring. The reaction mixture was aged for overnight, filtered and subsequently air dried to provide 3-methyl-2-morpholin-4-yl-2,3-dihydro-benzofuran-5-ol (628 g, 2.7 mol).

WORKUP

后处理

  1. temperaturecooled with a dry ice/isopropyl alcohol (IPA) bath
  2. filtrationfiltered
  3. customsubsequently air dried