HuagongsheHuagongshe Chemistry Print Report · For research reference only
Quinone → 3-Methyl-2-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Quinone | HCID 4650 | — |
| Reactant | 4-(Prop-1-en-1-yl)morpholine | HCID 54425487 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-Methyl-2-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-ol | HCID 13872995 | 96.4% |
Reaction Steps
Benzoquinone (300 g, 2.8 mol) was added in toluene (1.5 L) and cooled with a dry ice/isopropyl alcohol (IPA) bath. 4-Propenyl-morpholine (prepared as above in EXAMPLE I) (380 g, 3 mol) was added dropwise with stirring. The reaction mixture was aged for overnight, filtered and subsequently air dried to provide 3-methyl-2-morpholin-4-yl-2,3-dihydro-benzofuran-5-ol (628 g, 2.7 mol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212336B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-909b60085f2b42fe993991ecbf59c4df |
| Source note | uspto-grants-2015_12 |