反应详情

温度

56 °C

3-Methyl-2-morpholin-4-yl-2,3-dihydro-benzofuran-5-ol (prepared as above in EXAMPLE II) (628 g, 2.7 mol) was added to hydrochloric acid (HCl) (20%, 2 L) at room temperature with stirring. The reaction mixture was heated to 56° C. for 3 hours and then cooled down. The crude was extracted with toluene (500 mL) for three times. The organic phases were obtained, combined and evaporated to provide a crude product, which was further recrystallization to afford 3-methyl-benzofuran-5-ol (290 g, 2 mol).

1. temperaturecooled down
2. extractionThe crude was extracted with toluene (500 mL) for three times
3. customThe organic phases were obtained
4. customevaporated
5. customto provide a crude product, which
6. customrecrystallization