反应详情

3-Methyl-benzofuran-5-ol (prepared as above in EXAMPLE III) (245 g, 1.6 mol) was added in tetrahydrofuran (THF) (450 mL) and hydrogenated with palladium on carbon (Pd/C) (5%, 2.4 g) under hydrogen (H2) (200 psi) at 145° C. for about 8 hours till gas chromatograph (GC) analysis showed completion of the reaction. The obtained mixture was filtered and distilled to afford 3-methyl-2,3-dihydro-benzofuran-5-ol (190 g, 1.3 mol).

1. customcompletion of the reaction
2. filtrationThe obtained mixture was filtered
3. distillationdistilled