化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Phosphate, Tribasic → 2-Chloro-4-methoxytoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 反応物 | Methylboronic Acid | HCID 139377 | — |
| 反応物 | 1-Bromo-2-chloro-4-methoxybenzene | HCID 2756863 | — |
| 触媒 | HCID 178418807 | HCID 178418807 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Heptane | HCID 8900 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Chloro-4-methoxytoluene | HCID 6951757 | — |
反応手順
A solution of PdCl2(dppf)-DCM adduct (0.922 g, 1.129 mmol), methylboronic acid (2.70 g, 45.2 mmol), 4-bromo-3-chloroanisole (6.39 ml, 45.2 mmol), and potassium phosphate (28.8 g, 135 mmol) in 150 mL dioxane and 50 mL water was heated to 110° C. for 2 hours. The reaction mixture was then diluted with heptane, the organics dried over MgSO4 and concentrated to afford 2-chloro-4-methoxy-1-methylbenzene. m/z (ESI) 141.0 (M−CH3)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09212182B2 |
| 出典データセット | uspto-grants-2015_12 |
| ORD ID | ord-d6d0f1dc4f864c03a9e4c117381e18c0 |
| 出典メモ | uspto-grants-2015_12 |