Trifluoromethanesulfonic acid → HCID 117737018, compound

HRID 1504514Notes

Reaction equation

HRID 1504514 reaction equation
[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([S:19]([N:22]([C:32]4[CH:36]=[CH:35][O:34][N:33]=4)CC4C=CC(OC)=CC=4)(=[O:21])=[O:20])=[CH:16][CH:17]=3)[CH:12]=[CH:11][C:10]2=[O:37])=[C:4]([O:38][CH2:39][C:40]#[N:41])[CH:3]=1.FC(F)(F)S(O)(=O)=O>C(Cl)Cl>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N:9]2[C:18]3[C:13](=[CH:14][C:15]([S:19]([NH:22][C:32]4[CH:36]=[CH:35][O:34][N:33]=4)(=[O:20])=[O:21])=[CH:16][CH:17]=3)[CH:12]=[CH:11][C:10]2=[O:37])=[C:4]([O:38][CH2:39][C:40]#[N:41])[CH:3]=1

Participants

4

Reactant 2

HCID 62406Trifluoromethanesulfonic acidHCID 117737146HCID 117737146, compound

Product 1

HCID 117737018HCID 117737018, compoundYield 12.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(4-bromo-2-(cyanomethoxy)-5-fluorophenyl)-N-(isoxazol-3-yl)-N-(4-methoxybenzyl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide (53.1 mg, 0.083 mmol) in DCM (830 μl) at RT was added trifluoromethanesulfonic acid (22.11 μl, 0.249 mmol). The resulting solution was stirred for 2.5 hours and LCMS indicated that the reaction had not proceeded. Additional 0.010 mL was then added and the resulting mixture stirred for 16 hr. The reaction mixture was concentrated by sending a stream of N2 gas into the uncapped reaction vial. The residue was then dissolved in 1 ml of DMSO and 0.050 mL of saturated NaHCO3 was added and the resulting mixture was stirred for 5 minutes. The solution was then passed through a 0.20 micron filter. An additional 0.5 ml was used to sinse the reaction vial and the solution was passed through the same filter. The DMSO solution was purified by reverse-phase HPLC (Waters XBridge Prep Shield RP18 10 μm OBD 19×100 mm) gradient, 5 to 30% MeCN in water (containing 0.1% ammonium hydroxide as an additive), flow rate 40 mL/min to yield 1-(4-bromo-2-(cyanomethoxy)-5-fluorophenyl)-N-(isoxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide (5.2 mgs, 12% yield). 1H NMR (500 MHz, DMSO-d6) □=ppm 5.13-5.22 (m, 2 H) 6.22 (s, 1 H) 6.73 (dd, J=9.21, 4.41 Hz, 2 H) 7.70 (d, J=8.56 Hz, 1H) 7.75 (dd, J=8.92, 1.85 Hz, 1 H) 7.89 (d, J=6.10 Hz, 1 H) 8.18 (d, J=9.27 Hz, 1 H) 8.20-8.23 (m, 1 H) 8.37 (s, 1 H). m/z (ESI) 518.9 (M+H)+.

Workup

  1. additionAdditional 0.010 mL was then added
  2. stirringthe resulting mixture stirred for 16 hr
  3. concentrationThe reaction mixture was concentrated
  4. dissolutionThe residue was then dissolved in 1 ml of DMSO
  5. addition0.050 mL of saturated NaHCO3 was added
  6. stirringthe resulting mixture was stirred for 5 minutes
  7. filtrationfilter
  8. customThe DMSO solution was purified by reverse-phase HPLC (Waters XBridge Prep Shield RP18 10 μm OBD 19×100 mm) gradient, 5 to 30% MeCN in water (
  9. additioncontaining 0.1% ammonium hydroxide as an additive), flow rate 40 mL/min

Sources & evidence

ORD record
ord-a1eb1d71402b4634a367e6624c485d13
Source dataset
uspto-grants-2015_12
Patent number
US09212182B2

Reaction notes

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