Cyclopentanol → 6-(Cyclopentyloxy)-4-pyrimidinamine

HRID 1504560Notes

Reaction equation

HRID 1504560 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([NH2:12])[CH:7]=2)[CH2:3][CH2:2]1.[CH:13]1(O)CCCC1>>[CH:4]1([O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([NH2:12])[CH:7]=2)[CH2:1][CH2:3][CH2:2][CH2:13]1

Participants

3

Reactant 2

HCID 7298CyclopentanolHCID 80864926HCID 80864926, compound

Product 1

HCID 574765616-(Cyclopentyloxy)-4-pyrimidinamineYield 86%

Procedure

This was prepared in a manner analogous to 6-(cyclopropylmethoxy)pyrimidin-4-amine, where cyclopentanol was used as the alcohol. 6-(cyclopentyloxy)pyrimidin-4-amine (0.238 g, 1.328 mmol, 86% yield) was obtained as a white solid. m/z (ESI) 180.2 (M+H)+.

Sources & evidence

ORD record
ord-3afa207249cb47be950fa1f3c895d184
Source dataset
uspto-grants-2015_12
Patent number
US09212182B2

Reaction notes

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