51110-01-1 → 38916-34-6

HRID 1504744Notes

Reaction equation

HRID 1504744 reaction equation
[CH3:1][CH:2]([OH:115])[CH:3]1[NH:51][C:49](=[O:50])[CH:48]([CH2:52][CH2:53][CH2:54][CH2:55][NH2:56])[NH:47][C:45](=[O:46])[CH:44]([CH2:57][C:58]2[C:66]3[C:61](=[CH:62][CH:63]=[CH:64][CH:65]=3)[NH:60][CH:59]=2)[NH:43][C:41](=[O:42])[CH:40]([CH2:67][C:68]2[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=2)[NH:39][C:37](=[O:38])[CH:36]([CH2:74][C:75]2[CH:80]=[CH:79][CH:78]=[CH:77][CH:76]=2)[NH:35][C:33](=[O:34])[CH:32]([CH2:81][C:82]([NH2:84])=[O:83])[NH:31][C:29](=[O:30])[CH:28]([CH2:85][CH2:86][CH2:87][CH2:88][NH2:89])[NH:27][C:25](=[O:26])[CH:24]([NH:90][C:91]([CH2:93][NH:94][C:95]([CH:97]([NH2:99])[CH3:98])=[O:96])=[O:92])[CH2:23][S:22][S:21][CH2:20][CH:19]([C:100]([OH:102])=[O:101])[NH:18][C:16](=[O:17])[CH:15]([CH2:103][OH:104])[NH:14][C:12](=[O:13])[CH:11]([CH:105]([OH:107])[CH3:106])[NH:10][C:8](=[O:9])[CH:7]([CH2:108][C:109]2[CH:114]=[CH:113][CH:112]=[CH:111][CH:110]=2)[NH:6][C:4]1=[O:5]>[Cl-].[Na+]>[CH3:1][C@@H:2]([OH:115])[C@@H:3]1[NH:51][C:49](=[O:50])[C@H:48]([CH2:52][CH2:53][CH2:54][CH2:55][NH2:56])[NH:47][C:45](=[O:46])[C@H:44]([CH2:57][C:58]2[C:66]3[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=3[NH:60][CH:59]=2)[NH:43][C:41](=[O:42])[C@H:40]([CH2:67][C:68]2[CH:73]=[CH:72][CH:71]=[CH:70][CH:69]=2)[NH:39][C:37](=[O:38])[C@H:36]([CH2:74][C:75]2[CH:76]=[CH:77][CH:78]=[CH:79][CH:80]=2)[NH:35][C:33](=[O:34])[C@H:32]([CH2:81][C:82]([NH2:84])=[O:83])[NH:31][C:29](=[O:30])[C@H:28]([CH2:85][CH2:86][CH2:87][CH2:88][NH2:89])[NH:27][C:25](=[O:26])[C@@H:24]([NH:90][C:91]([CH2:93][NH:94][C:95]([C@@H:97]([NH2:99])[CH3:98])=[O:96])=[O:92])[CH2:23][S:22][S:21][CH2:20][C@@H:19]([C:100]([OH:102])=[O:101])[NH:18][C:16](=[O:17])[C@H:15]([CH2:103][OH:104])[NH:14][C:12](=[O:13])[C@H:11]([C@H:105]([OH:107])[CH3:106])[NH:10][C:8](=[O:9])[C@H:7]([CH2:108][C:109]2[CH:110]=[CH:111][CH:112]=[CH:113][CH:114]=2)[NH:6][C:4]1=[O:5]

Participants

3

Reactant 1

HCID 1612968151110-01-12×

Product 1

HCID 1612970638916-34-6

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent2×

Procedure

A pharmaceutical composition of somatostatin was prepared in 0.9% sodium chloride containing 20 mg of phosphatidyl choline and 2.7 mg of somatostatin-14 per mL. Briefly, phosphatidyl choline was slowly added under stirring to the 0.9% sodium chloride aqueous solution containing somatostatin-14. The composition was further stirred for 15 minutes until a liposome suspension was formed. Then liposomes were stepwise extruded through a polycarbonate filter with a 400 nm pore size, a 200 nm pore size filter and eventually ten times with a 100 nm pore size filter. Finally, the liposomal solution was filtered through a 0.22 μm sterilizing filter.

Workup

  1. customwas formed
  2. filtrationfilter with a 400 nm pore size
  3. filtrationa 200 nm pore size filter
  4. filtrationeventually ten times with a 100 nm pore size filter
  5. filtrationFinally, the liposomal solution was filtered through a 0.22 μm
  6. filtrationsterilizing filter

Sources & evidence

ORD record
ord-d19aca45f9e743319bd56c7133d6e9c1
Source dataset
uspto-grants-2015_12
Patent number
US09216208B2

Reaction notes

Loading…