2-Chloro-4-aminopyrimidine → HCID 86731670, compound

HRID 1504776Notes

Reaction equation

HRID 1504776 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=1.CC1N=C(N)C=C([N:17]2[N:21]=[CH:20][CH:19]=[N:18]2)C=1>>[N:18]1[N:17]([C:2]2[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N:3]=2)[N:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 3457522-Chloro-4-aminopyrimidineHCID 86731671HCID 86731671, compound

Product 1

HCID 86731670HCID 86731670, compound

Procedure

2-(2H-1,2,3-triazol-2-yl)pyrimidin-4-amine was prepared from 2-chloropyrimidin-4-amine using chemistry analogous to the synthesis of 6-methyl-4-(2H-1,2,3-triazol-2-yl)pyridin-2-amine (PrepEx 2.19 A). MS ESI calc'd. for C6H7N6 [M+H]+ 163. found 163. 1H NMR (500 MHz, DMSO-d6) δ 8.14 (d, J=5.5 Hz, 1H), 8.06 (s, 2H), 7.42 (s, 2H), 6.46 (d, J=5.5 Hz, 1H).

Sources & evidence

ORD record
ord-71540b7305ea48c4a699d032ccb7c1d5
Source dataset
uspto-grants-2015_12
Patent number
US09216173B2

Reaction notes

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