反应详情

A mixture of benzyl tert-butyl (3-ethoxypropane-1,2-diyl)biscarbamate (3.0 g, 8.5 mmol) in hydrochloric acid (4.0 M in methanol, 20 mL, 80 mmol) was stirred at ambient temperature. After 2 hours, the reaction mixture was concentrated under reduced pressure to give benzyl (2-amino-3-ethoxypropyl)carbamate. MS ESI calc'd. for C13H21N2O3 [M+H]+ 253. found 253. 1H NMR (400 MHz, CD3OD) δ 7.45-7.26 (m, 5H), 5.13 (s, 2H), 3.67-3.51 (m, 4H), 3.45-3.39 (m, 3H), 1.24 (t, J=7.0 Hz, 3H).

1. concentrationthe reaction mixture was concentrated under reduced pressure