Iodoethane → HCID 117973954, compound
Reaction equation
[CH:1]1([N:7]2[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:12]([I:14])[CH3:13]>>[I-:14].[CH2:12]([N+:7]1([CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH2:11][CH2:10][CH2:9][CH2:8]1)[CH3:13]Participants
3
Procedure
N-cyclohexylpyrrolidine prepared in example 1 was quaternized with ethyl iodide according to the procedure describe in example 4 (using ethyl iodide in place of methyl iodide). The reaction afforded N-Ethyl-N-cyclohexylpyrrolidinium iodide in 86% yield. The iodide salt was exchanged with Bio-Rad AG 1-X8 ion-exchange resin as described in example 4 for the N-methyl-N-cyclohexylpyrrolidinium iodide. The exchange procedure afforded N-ethyl-N-cyclohexylpyrrolidinium hydroxide in 89% yield (titration analysis).
Sources & evidence
- ORD record
- ord-dd3e0c1bfb744ad2a7d0364ce4369976
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09216911B2
Reaction notes
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