反应详情

To a solution of compound 24 (800 mg, 3.25 mmol) in EtOH (10 mL) was added concentrated HCl solution (12N, 5 mL). The mixture was heated at reflux for 1 h, cooled to room temperature, concentrated in vacuo. The resulting white solid was dissolved in EtOAc, washed with saturated aqueous NaHCO3, dried over Na2SO4 and concentrated to give compound 25 (660 mg, 99%) as a light yellow solid. 1H NMR (400 MHz, CDCl3) δ7.40 (d, 1H, J=7.2 Hz), 7.09 (d, 1H, J=10.0 Hz), 4.48 (br s, 2H).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 h
3. concentrationconcentrated in vacuo
4. dissolutionThe resulting white solid was dissolved in EtOAc
5. washwashed with saturated aqueous NaHCO3
6. dry with materialdried over Na2SO4
7. concentrationconcentrated