反应详情

To a solution of compound 27 (300 mg, 1.55 mmol) in CH3OH (5 mL) was added NH4OH (32) at room temperature with stirring. The reaction mixture was stirred at room temperature for 6 h and concentrated in vacuo. The residue was diluted with water and extracted with DCM/CH3OH (10:1). The combined organic layers were dried over Na2SO4 and concentrated to dryness to give compound 33 (194 mg, 70%) as a white solid. The crude product was used directly for the next step without purification.

1. stirringThe reaction mixture was stirred at room temperature for 6 h
2. concentrationconcentrated in vacuo
3. additionThe residue was diluted with water
4. extractionextracted with DCM/CH3OH (10:1)
5. dry with materialThe combined organic layers were dried over Na2SO4
6. concentrationconcentrated to dryness