反应详情

In an embodiment, fingolimod hydrochloride may be obtained by dissolving fingolimod of step b) in ethanol, cooling the reaction mixture to 0° C. to 5° C., adding ethanolic hydrochloride solution drop wise over a period of 10 to 30 minutes at the same temperature to obtain a suspension, maintaining the suspension at the same temperature for 1 to 3 hours, filtering the obtain solid, washing with an ether solvent and optionally drying the product obtained to give fingolimod hydrochloride.

1. temperaturecooling the reaction mixture to 0° C. to 5° C.
2. customto obtain a suspension
3. temperaturemaintaining the suspension at the same temperature for 1 to 3 hours
4. filtrationfiltering the obtain solid
5. washwashing with an ether solvent
6. customoptionally drying the product
7. customobtained