反应详情

To a microwave tube is added 2,3,5-trifluoropyridine (2.0 g, 15 mmol), concentrated HCl (12.5 mL, 150 mmol). The mixture is irradiated with microwave for 30 min at 130° C. The reaction mixture is cooled to ambient temperature, diluted with 100 mL of water, extracted with dichloromethane three times. The organic phase is further washed with brine, dried over Na2SO4 and dried to give 2-chloro-3,5-difluoropyridine as a greenish solid. The compound is used without further purification.

1. customThe mixture is irradiated with microwave for 30 min at 130° C
2. extractionextracted with dichloromethane three times
3. washThe organic phase is further washed with brine
4. dry with materialdried over Na2SO4
5. customdried