4-benzyloxy-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one → 4-[(e)-2-(4-Fluorophenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1h-pyridin-2-one

HRID 15051Notes

Reaction equation

HRID 15051 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][N:13]=[C:12]([O:16]CC3C=CC(OC)=CC=3)[CH:11]=2)=[CH:4][CH:3]=1.C(OC1C=CN([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH2:47][CH2:48][N:49]3[CH2:53][CH2:52][CH2:51][CH2:50]3)=[CH:42][CH:41]=2)C(=O)C=1)C1C=CC=CC=1.FC1C=CC(/C=C/C2C=CNC(=O)C=2)=CC=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][N:13]([C:40]3[CH:41]=[CH:42][C:43]([O:46][CH2:47][CH2:48][N:49]4[CH2:50][CH2:51][CH2:52][CH2:53]4)=[CH:44][CH:45]=3)[C:12](=[O:16])[CH:11]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 115020084-benzyloxy-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-oneHCID 668727254-[(E)-2-(4-fluorophenyl)vinyl]-2-(4-methoxybenzyloxy)-pyridineHCID 668728774-[(e)-2-(4-Fluorophenyl)vinyl]-1h-pyridin-2-one

Product 1

HCID 111888914-[(e)-2-(4-Fluorophenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1h-pyridin-2-one

Procedure

Operations similar to Steps (1), (2) and (3) of Example 12 were conducted except that 4-[(E)-2-(4-fluorophenyl)vinyl]-1H-pyridin-2-one was used in place of 4-benzyloxy-1H-pyridin-2-one in Example 12, to provide the title compound.

Sources & evidence

ORD record
ord-8b4f306bbce045648ac0402b91143577
Source dataset
uspto-grants-2010_06
Patent number
US07732456B2

Reaction notes

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