Hydrazine hydrate (1:1) → HCID 2800167, compound

HRID 1505331Notes

Reaction equation

HRID 1505331 reaction equation
O.NN.[CH3:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[O:12][C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][N:14]=1>C(O)C.[Pd]>[CH3:4][C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[O:12][C:13]1[N:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=1

Participants

5

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2800133HCID 2800133, compound2×

Product 1

HCID 2800167HCID 2800167, compoundYield 102.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

In a 50 mL round-bottomed flask 2-[(2,3-dimethylphenyl)oxy]-5-nitropyridine (Intermediate 37, 640 mg) was dissolved in ethanol (10 mL) to give a pale yellow solution. Hydrazine hydrate (0.463 mL, 4.72 mmol) and palladium on carbon (25.10 mg, 0.236 mmol) were added. The reaction mixture was stirred at 90° C. After 1 hour, the reaction was complete. The reaction mixture was filtered and the organic phase was evaporated in vacuo affording the title compound as a pale yellow oil (573 mg).

Workup

  1. customto give a pale yellow solution
  2. filtrationThe reaction mixture was filtered
  3. customthe organic phase was evaporated in vacuo

Sources & evidence

ORD record
ord-21f8958849c6476393cfbd77e9fd0e0e
Source dataset
uspto-grants-2015_12
Patent number
US09216967B2

Reaction notes

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