HCID 86673589, compound → HCID 67235532, compound

HRID 1505344Notes

Reaction equation

HRID 1505344 reaction equation
C[C@@H](NC(=O)[O-])C(NC1C=CC(OC2C=C(OC)C=CC=2C)=CC=1)=O.CC([N:30]([C@H:34]([CH3:54])[C:35]([NH:37][C:38]1[CH:39]=[N:40][C:41]([O:44][C:45]2[CH:50]=[C:49]([O:51][CH3:52])[CH:48]=[CH:47][C:46]=2[CH3:53])=[CH:42][CH:43]=1)=[O:36])C(=O)[O-])(C)C>>[CH3:53][C:46]1[CH:47]=[CH:48][C:49]([O:51][CH3:52])=[CH:50][C:45]=1[O:44][C:41]1[N:40]=[CH:39][C:38]([NH:37][C:35](=[O:36])[C@@H:34]([CH3:54])[NH2:30])=[CH:43][CH:42]=1

Participants

3

Reactant 2

HCID 86673589HCID 86673589, compoundHCID 866735901,1-dimethylethyl{(1R)-1-methyl-2-[(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate2×

Product 1

HCID 67235532HCID 67235532, compound

Procedure

The title compound was made in a similar fashion to the preparation of Intermediate 16 replacing {(1R)-1-methyl-2-[(4-{[2-methyl-5-(methyloxy)phenyl]oxy}phenyl)amino]-2-oxoethyl}carbamate with 1,1-dimethylethyl{(1R)-1-methyl-2-[(6-{[2-methyl-5-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate (Intermediate 55, 150 mg) to afford the title compound (120 mg).

Sources & evidence

ORD record
ord-5e5ed91a8569428a956fed834df3bb0a
Source dataset
uspto-grants-2015_12
Patent number
US09216967B2

Reaction notes

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