HCID 67236226, compound → HCID 61147393, compound

HRID 1505365Notes

Reaction equation

HRID 1505365 reaction equation
[CH3:1][CH:2]([C:4]1[CH:5]=[C:6]([O:10][C:11]2[N:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][N:12]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([C:4]1[CH:5]=[C:6]([O:10][C:11]2[N:16]=[CH:15][C:14]([NH2:17])=[CH:13][N:12]=2)[CH:7]=[CH:8][CH:9]=1)[CH3:1]

Participants

4

Reactant 1

HCID 67236226HCID 67236226, compound2×

Product 1

HCID 61147393HCID 61147393, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-{[3-(1-methylethyl)phenyl]oxy}-5-nitropyrimidine (Intermediate 84, 520 mg) in methanol (50 mL) was added Pd/C (10% wt., 100 mg) and the mixture was stirred under H2 atmosphere for 3 hours. The resulting mixture was filtered through a pad of celite and the filtrate was concentrated under vacuum to afford the title compound (400 mg).

Workup

  1. filtrationThe resulting mixture was filtered through a pad of celite
  2. concentrationthe filtrate was concentrated under vacuum

Sources & evidence

ORD record
ord-df7224bb15a0480aa34a9c3a1ca6a600
Source dataset
uspto-grants-2015_12
Patent number
US09216967B2

Reaction notes

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