反应详情

10.0 g (38.021 mmol) of the compound from Example 6A were initially charged in DMF (170 ml), and 9.41 g (41.823 mmol) of 2,3,6-trifluorobenzyl bromide and 13.62 g (41.82 mmol) of caesium carbonate were then added. The mixture was stirred at RT overnight. The reaction mixture was then added to water (200 ml) and stirred for 15 min A precipitate was filtered off with suction, washed with water and subsequently dried under high vacuum. This gave 12.1 g of the title compound (78% of theory).

1. stirringstirred for 15 min A precipitate
2. filtrationwas filtered off with suction
3. washwashed with water
4. customsubsequently dried under high vacuum