Sodium Hydroxide → HCID 56597206, compound

HRID 1505464Notes

Reaction equation

HRID 1505464 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:13]2[C:21]3[C:16](=[N:17][CH:18]=[CH:19][CH:20]=3)[N:15]([CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[F:29])[N:14]=2)[N:5]=[N:6][C:7]=1[CH2:8][C:9](OC)=[O:10].[OH-].[Na+]>CO>[F:29][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[CH2:22][N:15]1[C:16]2=[N:17][CH:18]=[CH:19][CH:20]=[C:21]2[C:13]([C:4]2[N:5]=[N:6][C:7]3[CH2:8][C:9](=[O:10])[NH:1][C:2]=3[N:3]=2)=[N:14]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131734350HCID 131734350, compound

Product 1

HCID 56597206HCID 56597206, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The intermediate from Step b) was dissolved in 350 ml of methanol, and 20 drops of a 1 N aqueous sodium hydroxide solution were added (pH=6). The mixture was stirred at RT overnight and concentrated on a rotary evaporator. The residue was purified on silica gel (mobile phase: dichloromethane/methanol, 96:4). This gave 67 mg (15% of theory) of the title compound.

Workup

  1. concentrationconcentrated on a rotary evaporator
  2. customThe residue was purified on silica gel (mobile phase: dichloromethane/methanol, 96:4)

Sources & evidence

ORD record
ord-61af5d4802e44e6095d3a75e2f81f400
Source dataset
uspto-grants-2015_12
Patent number
US09216978B2

Reaction notes

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