Hydrochloric Acid → HCID 86702965, compound

Participants

Reaction Steps

The tert-butyl-2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate (67 mg, 0.17 mmol) prepared at Step 4 was added into ethylacetate solvent and, hydrogen chloride (4M solution in 1,4-dioxane) was applied and stirred at room temperature for 5 hours. After the reaction, the solvent was concentrated and vacuum filtrated, and the remaining solid was washed with diethyl ether and hexane and dried, so that 55 mg of the target compound, N-(3-amino-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide (percentage yield: 99%), was obtained.

Provenance & Evidence