反应详情

The tert-butyl-2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate (67 mg, 0.17 mmol) prepared at Step 4 was added into ethylacetate solvent and, hydrogen chloride (4M solution in 1,4-dioxane) was applied and stirred at room temperature for 5 hours. After the reaction, the solvent was concentrated and vacuum filtrated, and the remaining solid was washed with diethyl ether and hexane and dried, so that 55 mg of the target compound, N-(3-amino-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide (percentage yield: 99%), was obtained.

1. customAfter the reaction
2. concentrationthe solvent was concentrated
3. filtrationvacuum filtrated
4. washthe remaining solid was washed with diethyl ether and hexane