Hydrochloric Acid → HCID 86702965, compound

HRID 1505528Notes

Reaction equation

HRID 1505528 reaction equation
C(OC(=O)[NH:7][C:8]1[C:13]([F:14])=[CH:12][CH:11]=[C:10]([NH:15][S:16]([C:19]2[N:20]=[CH:21][N:22]([CH3:24])[CH:23]=2)(=[O:18])=[O:17])[C:9]=1[F:25])(C)(C)C.Cl>C(OC(=O)C)C>[NH2:7][C:8]1[C:9]([F:25])=[C:10]([NH:15][S:16]([C:19]2[N:20]=[CH:21][N:22]([CH3:24])[CH:23]=2)(=[O:18])=[O:17])[CH:11]=[CH:12][C:13]=1[F:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131734352HCID 131734352, compound

Product 1

HCID 86702965HCID 86702965, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The tert-butyl-2,6-difluoro-3-(1-methyl-1H-imidazole-4-sulfonamido)phenylcarbamate (67 mg, 0.17 mmol) prepared at Step 4 was added into ethylacetate solvent and, hydrogen chloride (4M solution in 1,4-dioxane) was applied and stirred at room temperature for 5 hours. After the reaction, the solvent was concentrated and vacuum filtrated, and the remaining solid was washed with diethyl ether and hexane and dried, so that 55 mg of the target compound, N-(3-amino-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide (percentage yield: 99%), was obtained.

Workup

  1. customAfter the reaction
  2. concentrationthe solvent was concentrated
  3. filtrationvacuum filtrated
  4. washthe remaining solid was washed with diethyl ether and hexane

Sources & evidence

ORD record
ord-1a93d0103a064075887f49c8509a2c4b
Source dataset
uspto-grants-2015_12
Patent number
US09216981B2

Reaction notes

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