反应详情

1M aqueous hydrochloric acid solution was added into the N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-imidazole-4-sulfonamide (15 mg, 0.026 mmol) prepared at Step 8 and stirred for 2 hours. After the reaction, the reactant was washed with an aqueous solution of sodium hydrogen carbonate and salt water. After extraction with ethylacetate, the organic layer was dried with sulfuric anhydride magnesium and vacuum concentrated, and then refined by means of column chromatography, so that 11 mg of the target compound, N-(3-(3-(9H-purin-6-yl)pyridin-2-ylamino)-2,4-difluorophenyl)-1-methyl-1H-imidazole-4-sulfonamide (percentage yield: 88%), was obtained.

1. customprepared at Step 8
2. customAfter the reaction
3. washthe reactant was washed with an aqueous solution of sodium hydrogen carbonate and salt water
4. extractionAfter extraction with ethylacetate
5. dry with materialthe organic layer was dried with sulfuric anhydride magnesium and vacuum
6. concentrationconcentrated