反应详情

温度

7.5 °C

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (VI, 100 g) was dissolved in dichloromethane (500 ml) and Ethanol (150 mL) was added. The reaction mass was cooled to 5 to 10° C. N-bromosuccinimide (115 g) was added lot wise by maintaining temp below 10° C. Reaction mass was then stirred at 20-30° C. till completion of reaction. Reaction mass was washed with sodium bicarbonate solution (2%, 3×400 mL) and the organic layer was used for the next step.

1. temperatureby maintaining temp below 10° C
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4. washwas washed with sodium bicarbonate solution (2%, 3×400 mL)