反应详情

温度

41.5 °C

To the buffer solution (104.3 g of sodium dihydrogen orthophosphate dissolved in 530 mL of water & pH adjusted to 6.0-6.5 with saturated sodium bicarbonate solution (68 g in 680 mL water) solution) hexahydrofuro[2,3-b]furan-3-yl acetate (III, 115 g) and CAL-B (17.25 g) was added at 25-35° C., heated to 38-45° C. and stirred for 24 hours. CAL-B (17.25 g) was added stirred for 16 hours, again CAL-B (11.5 g) was added at 38-45° C. and stirred for 16 hours (pH should maintain 6.0-6.5). The reaction mass was cooled to 20-30° C., methylenedichloride (1150 mL) was added to the mass and stirred for 30 minutes. The reaction mass was filtered through hyflowbed then separated the organic layer and washed with 10% sodium chloride solution (575 mL). Organic layer was distilled completely under vacuum to get title compound II (yield 40.0 g).

1. additionwas added at 25-35° C.
2. additionCAL-B (17.25 g) was added
3. stirringstirred for 16 hours
4. additionagain CAL-B (11.5 g) was added at 38-45° C.
5. stirringstirred for 16 hours
6. temperature(pH should maintain 6.0-6.5)
7. temperatureThe reaction mass was cooled to 20-30° C.
8. stirringstirred for 30 minutes
9. filtrationThe reaction mass was filtered
10. customthrough hyflowbed then separated the organic layer
11. washwashed with 10% sodium chloride solution (575 mL)
12. distillationOrganic layer was distilled completely under vacuum