Diisopropylethylamine → HCID 86272861, compound

HRID 1505595Notes

Reaction equation

HRID 1505595 reaction equation
[NH2:1][C@H:2]([C:4]1[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]([F:28])([F:27])[C:23]([F:26])([F:25])[F:24])[CH:15]=2)[C:12](=[O:29])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[F:30])[N:5]=1)[CH3:3].Cl[C:32]1[C:33]2[CH:40]=[CH:39][NH:38][C:34]=2[N:35]=[CH:36][N:37]=1.C(N(C(C)C)CC)(C)C>CC(O)(C)C>[N:35]1[C:34]2[NH:38][CH:39]=[CH:40][C:33]=2[C:32]([NH:1][C@H:2]([C:4]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][C:22]([F:28])([F:27])[C:23]([F:24])([F:25])[F:26])[CH:15]=3)[C:12](=[O:29])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[F:30])[N:5]=2)[CH3:3])=[N:37][CH:36]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 53566827H-Pyrrolo(2,3-d)pyrimidine, 4-chloro-HCID 117599999HCID 117599999, compound

Product 1

HCID 86272861HCID 86272861, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Conditions

Temperature
120 °C

Procedure

Under nitrogen, to (S)-2-(1-aminoethyl)-5-fluoro-3-(3-(2,2,3,3,3-pentafluoropropoxy)phenyl)quinazolin-4(3H)-one (86 mg, 0.20 mmol, 1.0 equiv) in t-BuOH (0.2 mL) at 23° C. was added 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (34 mg, 0.22 mmol, 1.1 equiv) and diisopropylethylamine (70 μL, 0.40 mmol, 2.0 equiv). After stirring for 36 hr at 120° C. in a sealed tube, the reaction mixture was concentrated in vacuo and the residue was purified by preparative TLC eluting with CH2Cl2/MeOH to afford 12 mg of the title compound (11% yield).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. customthe residue was purified by preparative TLC
  3. washeluting with CH2Cl2/MeOH

Sources & evidence

ORD record
ord-9a436c21b47f4e9fb153716b90feb538
Source dataset
uspto-grants-2015_12
Patent number
US09216985B2

Reaction notes

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