Ammonia → HCID 90404094, compound

HRID 1505660Notes

Reaction equation

HRID 1505660 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[C:8]([C:12](OC)=[O:13])[NH:9]2)=[CH:5][C:4]=1[CH3:16].[NH3:17]>CO>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH:7]=[C:8]([C:12]([NH2:17])=[O:13])[NH:9]2)=[CH:5][C:4]=1[CH3:16]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 90404884HCID 90404884, compound

Product 1

HCID 90404094HCID 90404094, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

200 mg of methyl 6-methoxy-5-methyl-1H-indole-2-carboxylate (1 mmol) was heated at 80 degrees in a sealed tube with 2 mL of 7M ammonia in methanol. After one week reaction the solvent evaporated to produce 202 mg of 6-methoxy-5-methyl-1H-indole-2-carboxamide that was used without purification in the next step.

Workup

  1. customAfter one week reaction the solvent
  2. customevaporated

Sources & evidence

ORD record
ord-ddbc79c61a294e0686553482aac1ca44
Source dataset
uspto-grants-2015_12
Patent number
US09216993B2

Reaction notes

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