HCID 59615355, compound → HCID 84663096, compound

HRID 1505758Notes

Reaction equation

HRID 1505758 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([O:15][CH3:16])=[O:14])[C:7]2[N:11]=[CH:10][NH:9][C:8]=2[CH:12]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([O:15][CH3:16])=[O:14])[C:7]2[N:11]=[CH:10][NH:9][C:8]=2[CH:12]=1

Participants

4

Reactant 1

HCID 59615355HCID 59615355, compound

Product 1

HCID 84663096HCID 84663096, compoundYield 102.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl 6-nitro-1H-benzimidazole-4-carboxylate (304 mg) was suspended in MeOH (10 mL), the suspension was added with 5% palladium on carbon (30 mg), and stirred under hydrogen (1 atm) atmosphere. The catalyst was filtered off on celite and washed with MeOH, and the mother liquor was concentrated in vacuo to obtain the titled compound (269 mg) as pale yellow powder.

Workup

  1. filtrationThe catalyst was filtered off on celite
  2. washwashed with MeOH
  3. concentrationthe mother liquor was concentrated in vacuo

Sources & evidence

ORD record
ord-694f19957d5c4fa699832ad802009e5f
Source dataset
uspto-grants-2015_12
Patent number
US09216968B2

Reaction notes

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