反应详情

温度

100 °C

Methyl 2-amino-3-[(methoxyacetyl)amino]benzoate (280 mg) was dissolved in acetic acid (6 mL), and the solution was heated at 100° C. for 0.5 hour with stirring. After cooling the reaction mixture to room temperature, acetic acid was removed. To the residue was added saturated aqueous sodium bicarbonate under ice-cooling, and it was extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain the titled compound (241 mg) as pale yellow powder.

1. temperatureAfter cooling the reaction mixture to room temperature
2. customacetic acid was removed
3. additionTo the residue was added saturated aqueous sodium bicarbonate under ice-
4. temperaturecooling
5. extractionit was extracted with ethyl acetate
6. washThe organic layer was washed sequentially with water and brine
7. dry with materialdried over anhydrous magnesium sulfate
8. customthe solvent was removed under reduced pressure