Methyl 2-amino-3-[(methoxyacetyl)amino]benzoate → methyl 2-(methoxymethyl)-1H-benzo[d]imidazole-4-carboxylate

Participants

Reaction Conditions

Reaction Steps

Methyl 2-amino-3-[(methoxyacetyl)amino]benzoate (280 mg) was dissolved in acetic acid (6 mL), and the solution was heated at 100° C. for 0.5 hour with stirring. After cooling the reaction mixture to room temperature, acetic acid was removed. To the residue was added saturated aqueous sodium bicarbonate under ice-cooling, and it was extracted with ethyl acetate. The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain the titled compound (241 mg) as pale yellow powder.

Provenance & Evidence